LGD-4033

Introduction:

As we grow old, our body also starts to lose muscle strength, its mass, and leg power. Also, in certain conditions, like end-stage kidney disease, lung diseases, and some forms of cancer, loss of physical function is mainly attributed to the wasting of muscle mass resulting in limitation in mobility and disability. Additionally, with the growing desire of obtaining a muscular and bulkier body, many bodybuilding enthusiasts time and again follow a protein-rich diet along with a heavy workout regime. Unfortunately, when they fail to achieve the wished result quickly, they gravitate towards an altered diet plan and additional supplements to increase muscle mass.¹ (Basaria, S., 2013)

Thus, there is the requirement of an anabolic therapy to meet the needs of the gym enthusiast, reduce the burden caused by age/illness-induced physical disability, and enhance physical function. Amongst the many anabolic therapies in development, androgens have gained popularity and come along the farthest. Although testosterone administration increases strength and muscle mass, its potential negative effects on the prostate gland have caused a stir among the users and pushed the developers to find selective androgen receptor modulators (SARMs), a new variant of tissue-selective androgen receptor ligands. The previous decade has seen enormous efforts from the pharmaceuticals to develop non-steroidal SARM, one among them being LGD-4033.² (Dalton, J. T., 2011)

About LGD-4033:

LGD-4033 is a lab-created research substance. It has multiple organic molecules gripped together to shape into a complex. It is a pharmaceutical medicine designed by Ligand Pharmaceuticals to help people with muscle damage caused by the certain disorder, like breast cancer.³

As per the reviews of the user, it is an exceptionally good choice for bulking cycles and to achieve quick bulk up.  It presents promising results to any bodybuilding enthusiast, especially for those who are trying to achieve serious outcomes. LGD-4033 is highly effective in enhancing physical performance using increased strength besides increased size. There is a common belief regarding it that it helps in extending the workout time without making one feel tired and weary. In a nutshell, most of the consumers who have used it as a supplement have given it glorifying marks and referred it to others for use. Almost all users have found it satisfying in terms of achieving fitness goals, developing muscles, and cutting through the muscle-growing plateau.  Many believe that LGD-4033’s positive reviews lie in its capacity to provide fat-free, cleaner muscle.⁴

The science behind LGD-4033:

The attractive feature of LGD- 4033 is its ability to solely bind with androgen receptors present in the bone and muscle tissue and not with other androgen receptors in the liver, prostate, endocrine, and reproductive system. It helps in cutting fat, gaining clean lean muscle mass, increasing strength, and healing the bones.

SARM is seen as an ideal option for those who are beginners and are commencing their first cycle, due to its highly tolerable nature, excellent bioavailability, severe testosterone suppression is not seen, and it does not convert into estrogen, thus preventing increased manly breast formation ( because it is non-steroidal). Also, it is one of the few SARMs to have undergone successful clinical trials with promising results.^5,6 (Dalton, J. T., 2013)

How does LGD-4033 works?

As discussed above LGD-4033 binds selectively to muscle and bone tissue androgen receptors, in the sense that they will focus on specific receptors instead of forming a bond to every receptor they come across. In these bound receptors LGD- 4033 imitates the effect of androgen, thus helping in achieving more lean muscle mass, enhanced strength, quicker recovery time from injury, and improved quality of life.

In clinical studies, it was found that it reduces bone breakage/fracture and muscle wastage in addition to the increased anabolic process in bones and muscles among patients suffering from osteoporosis, cancer, old age, and muscular dystrophy. Furthermore, it reduces the body fat percentage along with improved physical performance. Now, with all the positive highlights it sounds like every gym goer, bodybuilder, and athlete’s dream, however, LGD-4033 isn’t completely 100% perfect, it too has its flaws.

Granted that it can quite successfully and rather quickly help in bulking up and cutting down fat, but, it was banned in 2008 by the World Anti-Doping agency (WADA), meaning if ever one gets tested positive for LGD-4033 in their urine/ blood sample, there is a risk of getting kicked out of the professional sports program.^4,5,6

Benefits of LGD-4033:

Following are the main benefits of LGD-4033, which makes it more preferred and famous among athletes and gymgoers.

1. Muscle mass increase:  This is the main reason why LGD-403 is the favorite among athletes. It targets the muscles immediately, and among SARMs, it is the most effective in boosting rapidly muscle growth. It even received much positive feedback about a gain in weight of approximately 10-15 pounds in the 1 LGD-4033 cycle. Studies have found its effectiveness in increasing muscle mass even at low doses. However, keep in mind to perform a good workout and eat a healthy diet, or else LGD-4033 will not be as effective or near ineffective.^1,5
2. Minimization of muscle damage: One daunting fear among body builders is muscle injury/damage due to rigorous exercise and inadequate diet. It presents a constant threat to bodybuilding. LGD-4033 reduces this damage a lot, considering this medicine was made to minimize muscle wastage/damage among cancer patients. Because of reduced muscle injury, it provides more time for training thus providing a double benefit.^1,4,5
3. Improved recovery: When we prepare for a competition recovery plays a crucial role. We cannot train well enough if we remain injured due to delayed healing. Thus, the sooner we recover, the sooner we can practice well leading to an expected result. The usual recovery time is around 72 hours after a rigorous workout which LGD-4033 reduces to 24 hours thus increasing the time for training. ^1,4,5
4. Cognitive brain function improvement: Besides the above-mentioned benefits of LGD-4033, there is an important usage of this medicine. It has been found to cross into the brain, thus having a mental effect apart from the physical advantages. It also provides sense wellbeing and stamina, thus causing mood enhancement and increased level of attention among the athletes, resulting in an increased capacity to compete. ^1,4,5
5. Increased strength: It has been witnessed that it immensely influences the strength of the athletes. It is not important when comes to health, but for bodybuilders, it provides increased strength thus giving them more energy to work harder. ^1,4,5

• Bone enhancement: Bones are the founding base of our body, it provides shape and muscles wrap around the bones. This means we cannot have great muscle mass if our bones are not strong and sturdy. Clinical trials have shown that LGD-4033 improves bone health and strength by increasing the nutrients that bones get. This explains the interest of researchers in using LGD-4033 for osteoporotic patients. Healthy bones lay a strong building for the muscle and body. ^1,4,5
• Cachexia: Compared to muscle wasting Cachexia is a broader term. It encompasses muscle atrophy, weight loss, and fatigue, it is commonly seen among cancer, AIDS, sepsis, and severe burn patients. Before LGD-4033, scientists studied various other drugs to combat this disorder, such as anabolic steroids that improved cachexia but had major setbacks due to their serious adverse effects like masculinization in women, and liver toxicity. Testosterone, also improved cachexia but came with a risk of prostate cancer, raised hematocrit, and affects the sexual organ. Being selective in nature LD-4033 brought relief to these patients. This medicine increased the survival among cachexia patients and helped them in tolerating intensive therapies( radio and chemotherapy). ^1,4,5

Side Effects of LGD-4033:

LGD-4033 is the most investigated one among all the SARM. It will be soon in the final stage of a clinical trial. Its side effects have not been recognized completely. However, it may cause a reduction of testosterone, sex hormone binding globulin, and water retention. It also reduces HDL cholesterol and triglyceride levels which tend to return to normal after the therapy. From the clinical trials, the reported side effects include dry mouth, headaches, and respiratory infection. ⁵

Who should not take LGD-4033:

• Anybody with a physical condition must consult a physician before taking this medicine.
• Below 18 years of age, nursing mother, and pregnant females must avoid consumption of LGD-4033.

Takeaway tip: Take medical advice before starting on LGD-4033. ⁵

Dosage:

LGD-4033 is available in various forms, such as capsules and tablets. As per experts, users can take up to 22mg safely. Although, it is advised to slowly start consuming LGD-4033 to build tolerance. Men’s tolerance levels differ from women’s. Many users have reported consuming the same dosage for bulking, cutting, and body recomposition cycle. Since there aren’t any long-term, high-quality clinical trials, there isn’t any safe, effective dose of LGD-4033. Commonly used dosages are:

•           Up to 5mg/day for women

•           Up to 10mg/day for men.⁵

Conclusion:

LGD-4033 has been reported so far as safe, with a favorable pharmacokinetic profile, and enhanced lean body mass, in most short-term clinical studies.  Longer randomized trials are required to evaluate its long-term effect and efficacy in ameliorating physical functioning in select populations.  Should one buy LGD-4033? Now, this is completely a personal question, and only the concerned person can answer. This miraculous medicine LGD-4033 has no doubt helped many of its users achieve their dream body via cutting, bulking, and strengthening bones. However, there are certain side effects to consider.  Keep in mind that, this drug is not FDA approved and if one is found guilty of taking it at a competition level, then one may be prohibited from further participation.¹ Having mentioned all the pros and cons of LGD-4033, one must remember that if consumed with medical consent and appropriately without abusing the drug, it has many potential advantages. This drug is safer than harmful steroidal formulations if consumed in suitable moderate amounts.

Disclaimer: “This product is intended for medical research purposes only. This product is not for human consumption. You must be a licensed and qualified healthcare practitioner to work with this product.”

Reference:

1. Basaria, S., Collins, L., Dillon, E. L., Orwoll, K., Storer, T. W., Miciek, R., Ulloor, J., Zhang, A., Eder, R., Zientek, H., Gordon, G., Kazmi, S., Sheffield-Moore, M., & Bhasin, S. (2013). The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The journals of gerontology. Series A, Biological sciences and medical sciences, 68(1), 87–95. https://doi.org/10.1093/gerona/gls078
2. Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011). The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. Journal of cachexia, sarcopenia and muscle, 2(3), 153–161. https://doi.org/10.1007/s13539-011-0034-6.
3. LGD 4033 Results 2022: Shocking Ligandrol Results Before and after 60 Days. (2022, August 9).Outlook. https://www.outlookindia.com/outlook-spotlight/lgd-4033-results-2022-shocking-ligandrol-results-before-and-after-60-days-news-214095
4. Ligandrol Reviews: Is This Legal Steroid Worth The Money? (2022, April28). The island now. https://theislandnow.com/blog-112/ligandrol-reviews/
5. Yazdi, P. What is Ligandrol (LGD 4033)? A Science-Based Review.(2021, November 3). Selfhacked. https://selfhacked.com/blog/lgd-4033-ligandrol-used-safe/
6. Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013). Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Current opinion in supportive and palliative care, 7(4), 345–351. https://doi.org/10.1097/SPC.0000000000000015

Disclaimer: “This product is intended for medical research purposes only. This product is not for human consumption. You must be a licensed and qualified healthcare practitioner to work with this product.”