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How does Clomid & Enclomiphene work for Post Cycle Therapy

Clomid vs. Enclomiphene in Post Cycle Therapy (PCT): A Comprehensive Comparison


Post Cycle Therapy (PCT) is a critical aspect of the bodybuilding and performance-enhancing world. It plays a crucial role in helping individuals recover their hormonal balance after a cycle of anabolic steroids or other performance-enhancing substances. Among the various medications used in PCT, Clomid (clomiphene citrate) and Enclomiphene have gained significant attention. In this comprehensive blog post, we will delve into the differences and similarities between Clomid and Enclomiphene in the context of PCT, helping you make an informed decision when planning your post-cycle recovery.

Understanding PCT

Before we dive into the specifics of Clomid and Enclomiphene, it’s essential to grasp the fundamental concept of Post Cycle Therapy. PCT is a protocol followed by athletes and bodybuilders who use anabolic steroids to enhance their performance. Anabolic steroids can suppress the body’s natural production of hormones, primarily testosterone, leading to various side effects such as reduced muscle mass, mood swings, and sexual dysfunction.

PCT aims to counteract these effects by restoring the body’s natural hormone production. This is typically done through the use of medications like Clomid and Enclomiphene, which are classified as Selective Estrogen Receptor Modulators (SERMs). These drugs work by influencing the hormonal balance within the body.

Now, let’s take a closer look at the two most popular SERMs used in PCT: Clomid and Enclomiphene.

Clomid (Clomiphene Citrate)

Clomid, also known as clomiphene citrate, is a widely used medication in the world of PCT. It was initially developed to treat female infertility by stimulating ovulation but has found its way into the bodybuilding community due to its ability to stimulate the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in both men and women.

  1. Mechanism of Action:
  • Clomid primarily works by blocking estrogen receptors in the hypothalamus, which leads to an increase in GnRH (Gonadotropin-Releasing Hormone) release. This, in turn, stimulates the pituitary gland to release more LH and FSH.
  • The increase in LH and FSH levels prompts the testes to produce more testosterone, aiding in the recovery of natural hormone production post-cycle.
  1. Dosage:
  • Typical Clomid dosages for PCT range from 50mg to 150mg per day.
  • PCT protocols often include a higher dose for the first week, followed by a tapering-down approach over several weeks.
  1. Side Effects:
  • Common side effects of Clomid include mood swings, hot flashes, visual disturbances, and abdominal discomfort.
  • In some cases, Clomid may have an anti-estrogenic effect on the body, potentially causing libido issues and joint pain.


Enclomiphene, also known as Androxal, is a newer SERM that is chemically similar to Clomid. While Clomid contains both enclomiphene and zuclomiphene, Enclomiphene consists of only the active enclomiphene isomer.

  1. Mechanism of Action:
  • Enclomiphene operates similarly to Clomid by blocking estrogen receptors in the hypothalamus, leading to increased GnRH release and subsequent LH and FSH production.
  • The main advantage of Enclomiphene is its higher selectivity for the estrogen receptor, potentially reducing some of the side effects associated with Clomid.
  1. Dosage:
  • Typical Enclomiphene dosages for PCT are similar to Clomid, ranging from 12.5mg to 50mg per day.
  • Like Clomid, Enclomiphene dosages may be tapered down during the PCT process.
  1. Side Effects:
  • Enclomiphene is generally considered to have a better side effect profile compared to Clomid. Users report fewer mood swings and visual disturbances.
  • However, it can still cause common side effects such as hot flashes and abdominal discomfort.

Comparing Clomid and Enclomiphene in PCT

Now that we have a basic understanding of how both Clomid and Enclomiphene work, let’s compare them in various aspects relevant to PCT.

  1. Effectiveness:
  • Both Clomid and Enclomiphene are effective in stimulating LH and FSH production, which helps restore testosterone levels during PCT.
  • Enclomiphene’s higher selectivity for the estrogen receptor may give it a slight edge in reducing side effects while achieving the same results.
  1. Side Effects:
  • Clomid has a more established history of use and is associated with a broader range of side effects, including mood swings and visual disturbances.
  • Enclomiphene, with its improved receptor selectivity, is generally considered to have a milder side effect profile.
  1. Cost:
  • Clomid is a generic medication and is often more affordable compared to brand-name Enclomiphene products.
  • Enclomiphene, being a newer and more specialized medication, can be more expensive.
  1. Availability:
  • Clomid is widely available as a generic medication and is prescribed for various medical conditions beyond PCT.
  • Enclomiphene may be less accessible, as it is a newer drug and may not be as readily available in all regions.
  1. User Preference:
  • Some users may prefer Clomid due to its longer history of use and familiarity.
  • Others may opt for Enclomiphene to potentially reduce side effects and achieve a smoother PCT experience.
  1. Individual Response: It’s essential to remember that individual responses to medications can vary widely. What works well for one person may not be as effective or tolerable for another.


In the world of Post Cycle Therapy, both Clomid and Enclomiphene are valuable tools for helping individuals recover their hormonal balance after a cycle of anabolic steroids or other performance-enhancing substances. While both medications operate on a similar principle—stimulating LH and FSH production through estrogen receptor blockade—Enclomiphene’s higher selectivity for the estrogen receptor may make it a more attractive option for those concerned about side effects.

Ultimately, the choice between Clomid and Enclomiphene should be based on individual preferences, experiences, and the guidance of a healthcare professional. It’s essential to consider factors such as cost, availability, and personal tolerance when making this decision. Additionally, monitoring hormone levels and working closely with a knowledgeable healthcare provider during PCT is crucial to ensure a successful and safe recovery process.

Always remember that the use of anabolic steroids and PCT medications should be approached with caution and responsibility, and they should only be used under the supervision of a healthcare professional. Your health and well-being should be the top priority as you navigate the world of performance enhancement and recovery.

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